MolNFT v1 · #187800 · protein

Human nalcn-FAM155A-UNC79-UNC80 channelosome with cam bound, conformation 1/2

7SX3 · Sodium leak channel non-selective PROTEIN,ENHANCED green…: “Human nalcn-FAM155A-UNC79-UNC80 channelosome with cam bound, conformation 1/2”. Electron microscopy, 4 ligands (PEV, Y01, PGV), 20 pockets (best druggability 0.86). MolNFT…

PDB: 7SX3
Type: protein
Length: 4,682 residues
Chains: 5
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sodium leak channel non-selective PROTEIN,ENHANCED green fluorescent protein…
UniProt: Q8IZF0, B1AL88, P0DP23, Q9P2D8, Q8N2C7
Ligands: PEV, Y01, PGV, NAG
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 5 distinct chains · 69% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sodium leak channel non-selective PROTEIN,ENHANCED green fluorescent protein	protein	1386	68% helix, 3% strand	Q8IZF0
B	Transmembrane protein FAM155A	protein	153	44% helix, 7% strand	B1AL88
C	Calmodulin-1	protein	114	54% helix, 0% strand	P0DP23
D	UNC79,PROTEIN unc-79 HOMOLOG,PROTEIN unc-79 homolog	protein	1418	75% helix, 0% strand	Q9P2D8
E	Protein unc-80 homolog	protein	1611	68% helix, 2% strand	Q8N2C7

Ligands and binding sites

PEV · (1S)-2-{[(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate · ligand · 4 copies · chains A, B
Y01 · Cholesterol hemisuccinate · ligand · 3 copies · chains A
PGV · (1R)-2-{[{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl (11E)-octadec-11-enoate · ligand · 2 copies · chains A
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	609	0.86	0.91	40	empty
2	1033	0.85	0.86	94	empty
3	1101	0.84	0.85	94	empty
4	979	0.81	0.82	102	empty
5	1165	0.81	0.82	114	empty

Interfaces

6 interfaces between chains.

D–E · 5885 Å² buried · 35 hydrogen bonds · protein-protein
A–B · 2488 Å² buried · 21 hydrogen bonds · protein-protein
A–E · 2400 Å² buried · 14 hydrogen bonds · protein-protein
A–C · 1458 Å² buried · 3 hydrogen bonds · protein-protein
A–D · 783 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 10 disulfide, 1 glycan, 1 modified (disulfide, N-glycosylation, sulfation).

Compared structures

7SX3 · Human NALCN-FAM155A-UNC79-UNC80 channelosome with CaM bound, conformation 1/2 · the same entry in another collection · chain E against E, TM-score 1.00
Q8IZF0 · AlphaFold monomer V2.0 prediction for sodium leak channel non- selective protein (Q8IZF0) · a predicted model of the same protein · chain A against A, TM-score 0.94
B1AL88 · AlphaFold monomer V2.0 prediction for transmembrane protein FAM155A (B1AL88) · a predicted model of the same protein · chain B against A, TM-score 0.88
P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain C against A, TM-score 0.45
Q9P2D8 · AlphaFold monomer V2.0 prediction for protein unc-79 homolog (Q9P2D8) · a predicted model of the same protein · chain D against A, TM-score 0.40

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IZF0
Every structure of UniProt B1AL88
Every structure of UniProt P0DP23
Every structure of UniProt Q9P2D8
Every structure of UniProt Q8N2C7
Elsewhere: RCSB PDB 7SX3 · PDBe 7SX3 · UniProt Q8IZF0 · UniProt B1AL88 · UniProt P0DP23 · UniProt Q9P2D8 · UniProt Q8N2C7

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