MolNFT v1 · #187550 · protein
Cryo-EM structure of the pr-rt components of the HIV-1 pol polyprotein
7SJX · Gag-pol polyprotein: “Cryo-EM structure of the pr-rt components of the HIV-1 pol polyprotein”. Electron microscopy, 19 pockets (best druggability 0.77). MolNFT v1 #187550 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SJX
- Type
- protein
- Length
- 1,137 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gag-pol polyprotein
- UniProt
- P03366
- Pockets
- 19 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 29% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gag-pol polyprotein | protein | 634 | 28% helix, 23% strand | P03366 |
| B | Gag-pol polyprotein | protein | 503 | 30% helix, 24% strand | P03366 |
Pockets
19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 982 | 0.77 | 0.79 | 62 | empty |
| 2 | 172 | 0.74 | 0.91 | 29 | empty |
| 3 | 571 | 0.73 | 0.81 | 75 | empty |
| 4 | 598 | 0.70 | 0.79 | 52 | empty |
| 5 | 373 | 0.70 | 0.83 | 36 | empty |
Interfaces
1 interface between chains.
- A–B · 4236 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 7SJX · Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 7SJX · PDBe 7SJX · UniProt P03366
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