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Cryo-EM structure of the pr-rt components of the HIV-1 pol polyprotein

Analyse Cryo-EM structure of the pr-rt components of the HIV-1 pol polyprotein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7SJX
Type: protein
Length: 1,137 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gag-pol polyprotein
UniProt: P03366
Pockets: 19 · best druggability 0.77

Structure

electron microscopy · 2 distinct chains · 29% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gag-pol polyprotein	protein	634	28% helix, 23% strand	P03366
B	Gag-pol polyprotein	protein	503	30% helix, 24% strand	P03366

Pockets

19 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	982	0.77	0.79	62	empty
2	172	0.74	0.91	29	empty
3	571	0.73	0.81	75	empty
4	598	0.70	0.79	52	empty
5	373	0.70	0.83	36	empty

Interfaces

1 interface between chains.

A–B · 4236 Å² buried · 38 hydrogen bonds · protein-protein

Compared structures

7SJX · Cryo-EM Structure of the PR-RT components of the HIV-1 Pol Polyprotein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03366
Elsewhere: RCSB PDB 7SJX · PDBe 7SJX · UniProt P03366

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