MolNFT v1 · #187460 · protein
LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
7SF7 · Isoform 1 of adhesion G protein-coupled receptor L3: “LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer”. Electron microscopy, 12 pockets (best druggability 0.80). MolNFT v1 #187460 on…
- PDB
- 7SF7
- Type
- protein
- Length
- 879 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform 1 of adhesion G protein-coupled receptor L3; G protein subunit 13 (GI2-mini-G13…
- UniProt
- P62873, P59768
- Pockets
- 12 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform 1 of adhesion G protein-coupled receptor L3 | protein | 275 | 64% helix, 0% strand | — |
| B | G protein subunit 13 (GI2-mini-G13 chimera) | protein | 213 | 37% helix, 16% strand | — |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 338 | 5% helix, 42% strand | P62873 |
| D | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 53 | 49% helix, 0% strand | P59768 |
Pockets
12 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1156 | 0.80 | 0.81 | 78 | empty |
| 2 | 902 | 0.74 | 0.78 | 84 | empty |
| 3 | 110 | 0.61 | 0.86 | 18 | empty |
| 4 | 255 | 0.58 | 0.79 | 22 | empty |
| 5 | 80 | 0.55 | 0.86 | 16 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1737 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 1073 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 912 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 53 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7SF7 · LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer · the same entry in another collection · chain A against A, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain C against A, TM-score 0.97
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain D against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7SF7 · PDBe 7SF7 · UniProt P62873 · UniProt P59768
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