MolNFT v1 · #187134 · protein

Crystal structure of the F337L mutation of trypanosoma cruzi glucokinase in the apo form (open conformation)

7S2N · Glucokinase 1: “Crystal structure of the F337L mutation of trypanosoma cruzi glucokinase in the apo form (open conformation)”. X-ray diffraction, 4 pockets (best druggability 0.75). MolNFT v1 #187134 on GenesisL1: 3D structure…

PDB: 7S2N
Type: protein
Length: 736 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucokinase 1
EC: 2.7.1.2
UniProt: Q4E4E1
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucokinase 1 (EC 2.7.1.2)	protein	369	44% helix, 24% strand	Q4E4E1
B	Glucokinase 1 (EC 2.7.1.2)	protein	367	44% helix, 24% strand	Q4E4E1

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1074	0.75	0.78	92	empty
2	53	0.72	0.99	21	empty
3	747	0.71	0.78	79	empty
4	78	0.36	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 1773 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7S2N · Crystal structure of the F337L mutation of Trypanosoma cruzi glucokinase in the apo form… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4E4E1
Elsewhere: RCSB PDB 7S2N · PDBe 7S2N · UniProt Q4E4E1

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