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Crystal structure of the F337L mutation of trypanosoma cruzi glucokinase in the apo form (open conformation)

Analyse Crystal structure of the F337L mutation of trypanosoma cruzi glucokinase in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7S2N
Type: protein
Length: 736 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucokinase 1
EC: 2.7.1.2
UniProt: Q4E4E1
Pockets: 4 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glucokinase 1 (EC 2.7.1.2)	protein	369	44% helix, 24% strand	Q4E4E1
B	Glucokinase 1 (EC 2.7.1.2)	protein	367	44% helix, 24% strand	Q4E4E1

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1074	0.75	0.78	92	empty
2	53	0.72	0.99	21	empty
3	747	0.71	0.78	79	empty
4	78	0.36	0.76	17	empty

Interfaces

1 interface between chains.

A–B · 1773 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

7S2N · Crystal structure of the F337L mutation of Trypanosoma cruzi glucokinase in the apo form… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4E4E1
Elsewhere: RCSB PDB 7S2N · PDBe 7S2N · UniProt Q4E4E1

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