MolNFT v1 · #187113 · protein
Structure of the human POT1-TPP1 complex
7S1T · Protection of telomeres protein 1: “Structure of the human POT1-TPP1 complex”. X-ray diffraction, 1 ligand (ZN), 20 pockets (best druggability 0.73). MolNFT v1 #187113 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7S1T
- Type
- protein
- Length
- 1,504 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protection of telomeres protein 1; Adrenocortical dysplasia protein homolog
- UniProt
- Q9NUX5, Q96AP0
- Ligands
- ZN
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G, J | Protection of telomeres protein 1 | protein | 302 | 21% helix, 33% strand | Q9NUX5 |
| B, E, H, K | Adrenocortical dysplasia protein homolog | protein | 74 | 47% helix, 1% strand | Q96AP0 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, D, G, J
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 490 | 0.73 | 0.82 | 52 | empty |
| 2 | 556 | 0.69 | 0.78 | 67 | empty |
| 3 | 50 | 0.68 | 0.97 | 17 | empty |
| 4 | 630 | 0.68 | 0.77 | 53 | empty |
| 5 | 383 | 0.67 | 0.81 | 40 | empty |
Interfaces
16 interfaces between chains.
- D–E · 2710 Ų buried · 36 hydrogen bonds · protein-protein
- J–K · 2653 Ų buried · 31 hydrogen bonds · protein-protein
- G–H · 2606 Ų buried · 29 hydrogen bonds · protein-protein
- A–B · 2601 Ų buried · 25 hydrogen bonds · protein-protein
- D–G · 741 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7S1T · Structure of the human POT1-TPP1 complex · the same entry in another collection · chain K against K, TM-score 1.00
- Q9NUX5 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (Q9NUX5) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q96AP0 · AlphaFold monomer V2.0 prediction for adrenocortical dysplasia protein homolog (Q96AP0) · a predicted model of the same protein · chain H against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NUX5
- Every structure of UniProt Q96AP0
- Elsewhere: RCSB PDB 7S1T · PDBe 7S1T · UniProt Q9NUX5 · UniProt Q96AP0
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