MolNFT v1 · #187048 · protein
Insulin degrading enzyme O/PC
7RZF · Cysteine-free insulin-degrading enzyme: “Insulin degrading enzyme O/PC”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #187048 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RZF
- Type
- protein
- Length
- 1,902 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine-free insulin-degrading enzyme; Insulin a chain; Insulin B chain
- EC
- 3.4.24.56
- UniProt
- P14735, P01308
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 4 distinct chains · 39% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 948 | 38% helix, 18% strand | P14735 |
| B | Cysteine-free insulin-degrading enzyme (EC 3.4.24.56) | protein | 940 | 40% helix, 17% strand | P14735 |
| a | Insulin a chain | protein | 9 | 0% helix, 11% strand | P01308 |
| b | Insulin B chain | protein | 5 | 0% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1127 | 0.85 | 0.86 | 99 | empty |
| 2 | 726 | 0.77 | 0.82 | 80 | empty |
| 3 | 1140 | 0.75 | 0.78 | 124 | empty |
| 4 | 617 | 0.74 | 0.81 | 71 | empty |
| 5 | 603 | 0.72 | 0.80 | 74 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1373 Ų buried · 16 hydrogen bonds · protein-protein
- A–a · 755 Ų buried · 9 hydrogen bonds · protein-protein
- A–b · 366 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7RZF · Insulin Degrading Enzyme O/pC · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14735
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7RZF · PDBe 7RZF · UniProt P14735 · UniProt P01308
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