MolNFT v1 · #187044 · protein
Structure of the complex of AMPA receptor GLUA2 with auxiliary subunit GSG1L bound to agonist quisqualate
7RZA · Glutamate receptor 2: “Structure of the complex of AMPA receptor GLUA2 with auxiliary subunit GSG1L bound to agonist quisqualate”. Electron microscopy, 1 ligand (QUS), 20 pockets (best druggability 0.83). MolNFT v1 #187044 on…
- PDB
- 7RZA
- Type
- protein
- Length
- 3,532 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- QUS
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 43% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor 2 | protein | 981 | 45% helix, 14% strand | P19491 |
| B, D | Glutamate receptor 2 | protein | 785 | 42% helix, 15% strand | P19491 |
Ligands and binding sites
- QUS · (S)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 784 | 0.83 | 0.86 | 92 | empty |
| 2 | 731 | 0.82 | 0.86 | 73 | empty |
| 3 | 170 | 0.80 | 0.96 | 22 | empty |
| 4 | 832 | 0.79 | 0.82 | 86 | empty |
| 5 | 554 | 0.78 | 0.85 | 72 | empty |
Interfaces
6 interfaces between chains.
- C–D · 4387 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 4362 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2762 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 2744 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 460 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 7RZA · Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to… · the same entry in another collection · chain D against D, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 7RZA · PDBe 7RZA · UniProt P19491
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.