Research workbench
Structure of the complex of AMPA receptor GLUA2 with auxiliary subunit GSG1L bound to agonist quisqualate
Analyse Structure of the complex of AMPA receptor GLUA2 with auxiliary subunit GSG1L… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7RZA
- Type
- protein
- Length
- 3,532 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- QUS
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 2 distinct chains · 43% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor 2 | protein | 981 | 45% helix, 14% strand | P19491 |
| B, D | Glutamate receptor 2 | protein | 785 | 42% helix, 15% strand | P19491 |
Ligands and binding sites
- QUS · (S)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 784 | 0.83 | 0.86 | 92 | empty |
| 2 | 731 | 0.82 | 0.86 | 73 | empty |
| 3 | 170 | 0.80 | 0.96 | 22 | empty |
| 4 | 832 | 0.79 | 0.82 | 86 | empty |
| 5 | 554 | 0.78 | 0.85 | 72 | empty |
Interfaces
6 interfaces between chains.
- C–D · 4387 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 4362 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2762 Ų buried · 16 hydrogen bonds · protein-protein
- A–D · 2744 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 460 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 7RZA · Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to… · the same entry in another collection · chain D against D, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.66
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 7RZA · PDBe 7RZA · UniProt P19491
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