MolNFT v1 · #186959 · protein
Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor compound 1
7RW5: “Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric…”. X-ray diffraction, 1 ligand (7U2). MolNFT v1 #186959 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RW5
- Type
- protein
- Length
- 1,475 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P31153
- Ligands
- 7U2
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 378 | — | P31153 |
| B | — | protein | 374 | — | P31153 |
| C | — | protein | 383 | — | P31153 |
| D | — | protein | 340 | — | P31153 |
Ligands and binding sites
- 7U2 · (3'R)-N-(cyclopropylmethyl)-1'-[(2-fluorophenyl) methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3'-pyrrolidin]-2-amine · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RW5 · Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · the same entry in another collection · chain A against A, TM-score 1.00
- P31153 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31153
- Elsewhere: RCSB PDB 7RW5 · PDBe 7RW5 · UniProt P31153
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