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Ligand · 7U2

7U2 · (3'R)-N-(cyclopropylmethyl)-1'-[(2-fluorophenyl) methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3'-pyrrolidin]-2-amine

7U2, (3'R)-N-(cyclopropylmethyl)-1'-[(2-fluorophenyl) methyl]-4-methyl-5H,7H-spiro[pyrano[4,3-d]pyrimidine-8,3'-pyrrolidin]-2-amine (C22 H27 F N4 O, 382.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
7U2
Formula
C22 H27 F N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

7U2 in 2 structures; the first of them:

  • 7RW5 · Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · 7U2 B402 · binds PHE139, GLY275, ALA276, LEU315, GLN317, SER331, ILE332, PHE333 and 10 more
  • 7RW5 · Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · 7U2 B402 · binds PHE139, GLY275, ALA276, LEU315, GLN317, SER331, ILE332, PHE333 and 10 more

Residues it binds most

PHE 2, GLY 2, GLN 2, LEU 2, ALA 2, ARG 2, GLU 2, ILE 2, SER 2, TRP 2 (residue and the binding sites it lines).

Found with

  • SAM · S-adenosylmethionine

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