MolNFT v1 · #186871 · protein
KRAS G12D in complex with compound 5B (7-(8-chloronaphthalen-1-yl)-8- fluoro-2-{[(2S)-1-methylpyrrolidin-2-YL]METHOXY}-4-(piperazin-1-yl) PYRIDO[4,3-D]PYRIMIDINE)
7RT4: “KRAS G12D in complex with compound 5B (7-(8-chloronaphthalen-1-yl)-8…”. X-ray diffraction, 3 ligands (GDP, 7IZ, MG). MolNFT v1 #186871 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7RT4
- Type
- protein
- Length
- 170 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Ligands
- GDP, 7IZ, MG
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 170 | — | — |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- 7IZ · 7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl) pyrido[4,3-d]pyrimidine · ligand · chains A
- MG · Magnesium ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7RT4 · KRAS G12D in complex with Compound 5B (7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-met… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 7RT4 · PDBe 7RT4
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