GL1X · GenesisL1 explorer

Ligand · 7IZ

7IZ · 7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl) pyrido[4,3-d]pyrimidine

7IZ, 7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl) pyrido[4,3-d]pyrimidine (C27 H28 Cl F N6 O, 507.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
7IZ
Formula
C27 H28 Cl F N6 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

7IZ in 2 structures; the first of them:

  • 7RT4 · KRAS G12D in complex with Compound 5B (7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2S)-1-met… · 7IZ A203 · binds VAL9, ASP12, ALA59, GLY60, GLN61, GLU62, GLU63, TYR64 and 10 more
  • 7RT4 · KRAS G12D in complex with compound 5B (7-(8-chloronaphthalen-1-yl)-8… · 7IZ A203 · binds VAL9, ASP12, ALA59, GLY60, GLN61, GLU62, GLU63, TYR64 and 10 more

Residues it binds most

ASP 2, ARG 2, GLN 2, GLU 2, TYR 2, VAL 2, ALA 2, GLY 2, HIS 2, ILE 2 (residue and the binding sites it lines).

Found with

  • GDP · Guanosine-5'-diphosphate
  • MG · Magnesium ion
  • GOL · Glycerol

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