MolNFT v1 · #185874 · protein
In vitro assembled tau filaments with structures like chronic traumatic encephalopathy type II (8A)
7QJW · Microtubule-associated protein tau: “In vitro assembled tau filaments with structures like chronic traumatic encephalopathy type II (8A)”. Electron microscopy, 4 pockets (best druggability 0.54). MolNFT v1 #185874 on GenesisL1: 3D…
- PDB
- 7QJW
- Type
- protein
- Length
- 450 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 4 · best druggability 0.54
Structure
electron microscopy · 1 distinct chain · 0% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Microtubule-associated protein tau | protein | 75 | 0% helix, 60% strand | P10636 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.54 | 0.79 | 25 | empty |
| 2 | 171 | 0.54 | 0.79 | 25 | empty |
| 3 | 72 | 0.44 | 0.82 | 16 | empty |
| 4 | 70 | 0.37 | 0.78 | 20 | empty |
Interfaces
11 interfaces between chains.
- A–C · 3240 Ų buried · 82 hydrogen bonds · protein-protein
- B–D · 3235 Ų buried · 87 hydrogen bonds · protein-protein
- B–F · 3226 Ų buried · 86 hydrogen bonds · protein-protein
- A–E · 3198 Ų buried · 79 hydrogen bonds · protein-protein
- B–C · 219 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7QJW · In vitro assembled tau filaments with structures like chronic traumatic encephalopathy… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QJW · PDBe 7QJW · UniProt P10636
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