Research workbench
In vitro assembled tau filaments with structures like chronic traumatic encephalopathy type II (8A)
Analyse In vitro assembled tau filaments with structures like chronic traumatic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7QJW
- Type
- protein
- Length
- 450 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Microtubule-associated protein tau
- UniProt
- P10636
- Pockets
- 4 · best druggability 0.54
Structure
electron microscopy · 1 distinct chain · 0% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Microtubule-associated protein tau | protein | 75 | 0% helix, 60% strand | P10636 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.54 | 0.79 | 25 | empty |
| 2 | 171 | 0.54 | 0.79 | 25 | empty |
| 3 | 72 | 0.44 | 0.82 | 16 | empty |
| 4 | 70 | 0.37 | 0.78 | 20 | empty |
Interfaces
11 interfaces between chains.
- A–C · 3240 Ų buried · 82 hydrogen bonds · protein-protein
- B–D · 3235 Ų buried · 87 hydrogen bonds · protein-protein
- B–F · 3226 Ų buried · 86 hydrogen bonds · protein-protein
- A–E · 3198 Ų buried · 79 hydrogen bonds · protein-protein
- B–C · 219 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 7QJW · In vitro assembled tau filaments with structures like chronic traumatic encephalopathy… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10636
- Elsewhere: RCSB PDB 7QJW · PDBe 7QJW · UniProt P10636
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