MolNFT v1 · #185133 · protein
Low resolution cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1
7PG2 · Isoform short of insulin receptor: “Low resolution cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1”. Electron microscopy, 16 pockets (best druggability 0.84). MolNFT v1 #185133 on GenesisL1: 3D…
- PDB
- 7PG2
- Type
- protein
- Length
- 1,742 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isoform short of insulin receptor; Insulin
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 16 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 11% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 786 | 8% helix, 32% strand | P06213 |
| B | Isoform short of insulin receptor (EC 2.7.10.1) | protein | 822 | 11% helix, 26% strand | P06213 |
| C, E, I | Insulin | protein | 21 | 48% helix, 0% strand | P01308 |
| D | Insulin | protein | 25 | 32% helix, 0% strand | P01308 |
| F, J | Insulin | protein | 23 | 48% helix, 0% strand | P01308 |
Pockets
16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 925 | 0.84 | 0.85 | 103 | empty |
| 2 | 144 | 0.82 | 0.97 | 29 | empty |
| 3 | 85 | 0.75 | 0.96 | 22 | empty |
| 4 | 552 | 0.63 | 0.75 | 49 | empty |
| 5 | 588 | 0.63 | 0.74 | 52 | empty |
Interfaces
14 interfaces between chains.
- A–B · 2626 Ų buried · 27 hydrogen bonds · protein-protein
- E–F · 660 Ų buried · 13 hydrogen bonds · protein-protein
- B–D · 627 Ų buried · 4 hydrogen bonds · protein-protein
- B–J · 623 Ų buried · 8 hydrogen bonds · protein-protein
- I–J · 605 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 47 disulfide (disulfide).
Compared structures
- 7PG2 · Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7PG2 · PDBe 7PG2 · UniProt P06213 · UniProt P01308
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