MolNFT v1 · #184977 · protein
Cryo EM structure of system xc- in complex with glutamate
7P9U · 4F2 cell-surface antigen heavy chain: “Cryo EM structure of system xc- in complex with glutamate”. Electron microscopy, 1 ligand (GLU), 8 pockets (best druggability 0.73). MolNFT v1 #184977 on GenesisL1: 3D structure, binding sites…
- PDB
- 7P9U
- Type
- protein
- Length
- 502 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4F2 cell-surface antigen heavy chain; CYSTINE/GLUTAMATE transporter
- UniProt
- P08195, Q9UPY5
- Ligands
- GLU
- Pockets
- 8 · best druggability 0.73
Structure
electron microscopy · 2 distinct chains · 69% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 4F2 cell-surface antigen heavy chain | protein | 47 | 62% helix, 0% strand | P08195 |
| B | CYSTINE/GLUTAMATE transporter | protein | 455 | 69% helix, 1% strand | Q9UPY5 |
Ligands and binding sites
- GLU · Glutamic acid · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 457 | 0.73 | 0.82 | 52 | GLU |
| 2 | 283 | 0.60 | 0.78 | 26 | empty |
| 3 | 132 | 0.53 | 0.81 | 20 | empty |
| 4 | 181 | 0.46 | 0.74 | 25 | empty |
| 5 | 51 | 0.41 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1066 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7P9U · Cryo EM structure of System XC- in complex with glutamate · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UPY5 · AlphaFold monomer V2.0 prediction for CYSTINE/GLUTAMATE transporter (Q9UPY5) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P08195 · AlphaFold monomer V2.0 prediction for 4F2 cell-surface antigen heavy chain (P08195) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08195
- Every structure of UniProt Q9UPY5
- Elsewhere: RCSB PDB 7P9U · PDBe 7P9U · UniProt P08195 · UniProt Q9UPY5
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