UniProt P08195
4F2 cell-surface antigen heavy chain (P08195)
4F2 cell-surface antigen heavy chain (UniProt P08195): 20 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 50 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08195
- Protein
- 4F2 cell-surface antigen heavy chain
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 50 · 7 records with a druggable one
Structures
21 records of P08195 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DH2 | Crystal Structure of human ED-4F2hc | x-ray diffraction | A | — | — |
| 2DH2 | Crystal structure of human ed-4F2HC | x-ray diffraction | A | — | — |
| 2DH3 | Crystal Structure of human ED-4F2hc | x-ray diffraction | A, B | — | — |
| 2DH3 | Crystal structure of human ed-4F2HC | x-ray diffraction | A, B | — | — |
| 6JMQ | LAT1-CD98hc complex bound to MEM-108 Fab | electron microscopy | B | NAG, CLR | — |
| 6JMQ | LAT1-CD98HC complex bound to mem-108 Fab | electron microscopy | B | NAG, CLR | — |
| 6JMR | CD98hc extracellular domain bound to HBJ127 Fab and MEM-108 Fab | electron microscopy | B | NAG | — |
| 6JMR | CD98HC extracellular domain bound to HBJ127 Fab and mem-108 Fab | electron microscopy | B | NAG | — |
| 6S8V | Structure of the high affinity anticalin P3D11 in complex with the human CD98 heavy chain ectodomain | x-ray diffraction | B, D | — | — |
| 7B00 | Human LAT2-4F2HC complex in the apo-state | electron microscopy | B | NAG | — |
| 7CCS | Consensus mutated xCT-CD98hc complex | electron microscopy | A | — | 6 (best 0.64) |
| 7CCS | Consensus mutated xct-CD98HC complex | electron microscopy | A | — | — |
| 7DF1 | Crystal structure of human CD98 heavy chain extracellular domain in complex with S1-F4 scFv | x-ray diffraction | A, B, C, D | — | 12 (best 0.75) |
| 7P9U | Cryo EM structure of system xc- in complex with glutamate | electron microscopy | A | — | — |
| 7P9V | Cryo EM structure of system xc- | electron microscopy | A | NAG | — |
| 8G0M | Structure of complex between TV6.6 and CD98hc ECD | x-ray diffraction | A | — | 3 (best 0.61) |
| 8J8L | Overall structure of the LAT1-4F2hc bound with L-dopa | electron microscopy | A | NAG | 10 (best 0.60) |
| 8J8M | Overall structure of the LAT1-4F2hc bound with tryptophan | electron microscopy | A | NAG | 7 (best 0.79) |
| 8WNS | Cryo EM map of SLC7A10 in the apo state | electron microscopy | A | NAG | 7 (best 0.62) |
| 8WNT | Cryo EM map of SLC7A10 with L-Alanine substrate | electron microscopy | A | NAG | 5 (best 0.65) |
| P08195 | AlphaFold monomer V2.0 prediction for 4F2 cell-surface antigen heavy chain (P08195) | predicted | A | — | — |
Ligands
Experiment against prediction
- 2DH2 chain A against the predicted model P08195: TM-score 0.99, RMSD 0.74 Å
- 2DH2 chain A against the predicted model P08195: TM-score 0.99, RMSD 0.74 Å
- 7DF1 chain B against the predicted model P08195: TM-score 0.99, RMSD 0.69 Å
- 7DF1 chain A against the predicted model P08195: TM-score 0.99, RMSD 0.71 Å
- 7DF1 chain D against the predicted model P08195: TM-score 0.99, RMSD 0.75 Å
- 7DF1 chain C against the predicted model P08195: TM-score 0.99, RMSD 0.75 Å
- 8G0M chain A against the predicted model P08195: TM-score 0.99, RMSD 0.84 Å
- 6JMQ chain B against the predicted model P08195: TM-score 0.99, RMSD 0.95 Å
- 6JMQ chain B against the predicted model P08195: TM-score 0.99, RMSD 0.95 Å
- 2DH3 chain B against the predicted model P08195: TM-score 0.99, RMSD 0.93 Å
Elsewhere
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