MolNFT v1 · #184912 · protein
The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1
7P73 · Synaptojanin-2-binding PROTEIN,ANNEXIN A2: “The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1”. X-ray diffraction, 1 ligand (CA), 4 pockets (best druggability 0.63). MolNFT v1 #184912 on GenesisL1: 3D…
- PDB
- 7P73
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Synaptojanin-2-binding PROTEIN,ANNEXIN A2; Protein tax-1
- UniProt
- P57105, P07355, P03409
- Ligands
- CA
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 57% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Synaptojanin-2-binding PROTEIN,ANNEXIN A2 | protein | 420 | 58% helix, 10% strand | P57105, P07355 |
| B | Protein tax-1 | protein | 6 | 0% helix, 33% strand | P03409 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 215 | 0.63 | 0.83 | 36 | GOL |
| 2 | 171 | 0.51 | 0.78 | 33 | GOL |
| 3 | 102 | 0.33 | 0.73 | 16 | empty |
| 4 | 51 | 0.27 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 555 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 7P73 · The PDZ domain of SYNJ2BP complexed with the PDZ-binding motif of HTLV1-TAX1 · the same entry in another collection · chain A against A, TM-score 1.00
- P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 0.76
- P57105 · AlphaFold monomer V2.0 prediction for synaptojanin-2-binding protein (P57105) · a predicted model of the same protein · chain A against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P57105
- Every structure of UniProt P07355
- Every structure of UniProt P03409
- Elsewhere: RCSB PDB 7P73 · PDBe 7P73 · UniProt P57105 · UniProt P07355 · UniProt P03409
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