MolNFT v1 · #184463 · protein
Cryo-EM structure of human TMEM45A
7OQZ · Transmembrane protein 45A: “Cryo-EM structure of human TMEM45A”. Electron microscopy, 1 ligand (PC1), 18 pockets (best druggability 0.80). MolNFT v1 #184463 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OQZ
- Type
- protein
- Length
- 948 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transmembrane protein 45A
- UniProt
- Q9NWC5
- Ligands
- PC1
- Pockets
- 18 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transmembrane protein 45A | protein | 237 | 79% helix, 0% strand | Q9NWC5 |
Ligands and binding sites
- PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 16 copies · chains A, B, D, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 536 | 0.80 | 0.85 | 51 | PC1 |
| 2 | 207 | 0.76 | 0.90 | 33 | empty |
| 3 | 211 | 0.76 | 0.90 | 35 | empty |
| 4 | 219 | 0.75 | 0.89 | 36 | empty |
| 5 | 228 | 0.75 | 0.89 | 35 | empty |
Interfaces
4 interfaces between chains.
- B–C · 1184 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 1169 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 1157 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 1156 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NWC5
- Elsewhere: RCSB PDB 7OQZ · PDBe 7OQZ · UniProt Q9NWC5
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