Research workbench

Cryo-EM structure of human TMEM45A

Analyse Cryo-EM structure of human TMEM45A in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7OQZ
Type: protein
Length: 948 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transmembrane protein 45A
UniProt: Q9NWC5
Ligands: PC1
Pockets: 18 · best druggability 0.80

Structure

electron microscopy · 1 distinct chain · 79% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Transmembrane protein 45A	protein	237	79% helix, 0% strand	Q9NWC5

Ligands and binding sites

PC1 · 1,2-diacyl-sn-glycero-3-phosphocholine · ligand · 16 copies · chains A, B, D, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	536	0.80	0.85	51	PC1
2	207	0.76	0.90	33	empty
3	211	0.76	0.90	35	empty
4	219	0.75	0.89	36	empty
5	228	0.75	0.89	35	empty

Interfaces

4 interfaces between chains.

B–C · 1184 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 1169 Å² buried · 2 hydrogen bonds · protein-protein
C–D · 1157 Å² buried · 1 hydrogen bond · protein-protein
A–D · 1156 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

7OQZ · Cryo-EM structure of human TMEM45A · the same entry in another collection · chain A against A, TM-score 1.00
Q9NWC5 · AlphaFold monomer V2.0 prediction for transmembrane protein 45A (Q9NWC5) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NWC5
Elsewhere: RCSB PDB 7OQZ · PDBe 7OQZ · UniProt Q9NWC5

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