MolNFT v1 · #184300 · protein
Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex
7OLE · Ruvb-like 1: “Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex”. Electron microscopy, 1 ligand (ADP), 20 pockets (best druggability 0.87). MolNFT v1 #184300 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OLE
- Type
- protein
- Length
- 4,023 residues
- Chains
- 9
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ruvb-like 1; Ruvb-like 2; TELO2-interacting protein 1 HOMOLOG,TELO2-interacting protein 1…
- EC
- 3.6.4.12
- UniProt
- Q9Y265, Q9Y230, O43156, Q6NXR4, Q9Y4R8
- Ligands
- ADP
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 9 distinct chains · 50% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ruvb-like 1 (EC 3.6.4.12) | protein | 433 | 25% helix, 9% strand | Q9Y265 |
| B | Ruvb-like 2 (EC 3.6.4.12) | protein | 418 | 33% helix, 15% strand | Q9Y230 |
| C | Ruvb-like 1 (EC 3.6.4.12) | protein | 427 | 34% helix, 17% strand | Q9Y265 |
| D | Ruvb-like 2 (EC 3.6.4.12) | protein | 419 | 36% helix, 10% strand | Q9Y230 |
| E | Ruvb-like 1 (EC 3.6.4.12) | protein | 413 | 38% helix, 17% strand | Q9Y265 |
| F | Ruvb-like 2 (EC 3.6.4.12) | protein | 419 | 35% helix, 18% strand | Q9Y230 |
| H | TELO2-interacting protein 1 HOMOLOG,TELO2-interacting protein 1 HOMOLOG,TTI1 | protein | 644 | 77% helix, 0% strand | O43156 |
| J | TELO2-interacting protein 2,TELO2-interacting protein 2, TTI2 | protein | 456 | 80% helix, 0% strand | Q6NXR4 |
| K | Telomere length regulation protein TEL2 homolog | protein | 394 | 78% helix, 0% strand | Q9Y4R8 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 5 copies · chains B, C, D, E, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 745 | 0.87 | 0.90 | 119 | empty |
| 2 | 1066 | 0.85 | 0.85 | 100 | ADP |
| 3 | 1131 | 0.83 | 0.84 | 93 | ADP |
| 4 | 715 | 0.82 | 0.86 | 120 | empty |
| 5 | 543 | 0.82 | 0.88 | 67 | empty |
Interfaces
11 interfaces between chains.
- A–B · 2773 Ų buried · 42 hydrogen bonds · protein-protein
- C–D · 1902 Ų buried · 19 hydrogen bonds · protein-protein
- E–F · 1856 Ų buried · 6 hydrogen bonds · protein-protein
- A–F · 1794 Ų buried · 27 hydrogen bonds · protein-protein
- B–C · 1791 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 covalent (covalent ligand).
Compared structures
- 7OLE · Cryo-EM structure of the TELO2-TTI1-TTI2-RUVBL1-RUVBL2 complex · the same entry in another collection · chain K against K, TM-score 1.00
- Q9Y4R8 · AlphaFold monomer V2.0 prediction for telomere length regulation protein TEL2 homolog… · a predicted model of the same protein · chain K against A, TM-score 0.85
- O43156 · AlphaFold monomer V2.0 prediction for TELO2-interacting protein 1 homolog (O43156) · a predicted model of the same protein · chain H against A, TM-score 0.85
- Q9Y265 · AlphaFold monomer V2.0 prediction for ruvb-like 1 (Q9Y265) · a predicted model of the same protein · chain A against A, TM-score 0.59
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y265
- Every structure of UniProt Q9Y230
- Every structure of UniProt O43156
- Every structure of UniProt Q6NXR4
- Every structure of UniProt Q9Y4R8
- Elsewhere: RCSB PDB 7OLE · PDBe 7OLE · UniProt Q9Y265 · UniProt Q9Y230 · UniProt O43156 · UniProt Q6NXR4 · UniProt Q9Y4R8
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