MolNFT v1 · #184213 · protein
Crystal structure of AP2 MU2 - FCHO2 chimera (HIS6-tagged)
7OHZ · Ap-2 complex subunit MU,F-bar domain only protein 2: “Crystal structure of AP2 MU2 - FCHO2 chimera (HIS6-tagged)”. X-ray diffraction, 5 pockets (best druggability 0.78). MolNFT v1 #184213 on GenesisL1: 3D structure, binding sites…
- PDB
- 7OHZ
- Type
- protein
- Length
- 570 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit MU,F-bar domain only protein 2
- UniProt
- P84092, Q0JRZ9
- Pockets
- 5 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Ap-2 complex subunit MU,F-bar domain only protein 2 | protein | 285 | 3% helix, 53% strand | P84092, Q0JRZ9 |
| A | Ap-2 complex subunit MU,F-bar domain only protein 2 | protein | 285 | 4% helix, 52% strand | P84092, Q0JRZ9 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1172 | 0.78 | 0.80 | 95 | empty |
| 2 | 98 | 0.37 | 0.75 | 15 | empty |
| 3 | 53 | 0.29 | 0.75 | 13 | empty |
| 4 | 65 | 0.27 | 0.73 | 21 | empty |
| 5 | 51 | 0.24 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- B–A · 580 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 7OHZ · Crystal structure of AP2 Mu2 - FCHO2 chimera (His6-tagged) · the same entry in another collection · chain B against B, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain A against A, TM-score 0.86
- Q0JRZ9 · AlphaFold monomer V2.0 prediction for F-bar domain only protein 2 (Q0JRZ9) · a predicted model of the same protein · chain A against A, TM-score 0.69
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Every structure of UniProt Q0JRZ9
- Elsewhere: RCSB PDB 7OHZ · PDBe 7OHZ · UniProt P84092 · UniProt Q0JRZ9
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