MolNFT v1 · #184187 · protein
Folded elbow of cohesin
7OGT · Structural maintenance of chromosomes protein 1: “Folded elbow of cohesin”. Electron microscopy, 12 pockets (best druggability 0.77). MolNFT v1 #184187 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OGT
- Type
- protein
- Length
- 1,396 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Structural maintenance of chromosomes protein 1; Structural maintenance of chromosomes…
- UniProt
- P32908, P47037
- Pockets
- 12 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 84% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Structural maintenance of chromosomes protein 1 | protein | 688 | 84% helix, 3% strand | P32908 |
| B | Structural maintenance of chromosomes protein 3 | protein | 708 | 83% helix, 4% strand | P47037 |
Pockets
12 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 522 | 0.77 | 0.84 | 59 | empty |
| 2 | 79 | 0.69 | 0.93 | 20 | empty |
| 3 | 79 | 0.68 | 0.93 | 26 | empty |
| 4 | 163 | 0.65 | 0.86 | 29 | empty |
| 5 | 93 | 0.54 | 0.85 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 2147 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 7OGT · Folded elbow of cohesin · the same entry in another collection · chain A against A, TM-score 1.00
- P47037 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 3… · a predicted model of the same protein · chain B against A, TM-score 0.70
- P32908 · AlphaFold monomer V2.0 prediction for structural maintenance of chromosomes protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.60
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32908
- Every structure of UniProt P47037
- Elsewhere: RCSB PDB 7OGT · PDBe 7OGT · UniProt P32908 · UniProt P47037
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