MolNFT v1 · #184154 · protein
Apo structure of MU2 adaptin subunit (AP50) of AP2 clathrin adaptor
7OFP · Ap-2 complex subunit mu: “Apo structure of MU2 adaptin subunit (AP50) of AP2 clathrin adaptor”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #184154 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OFP
- Type
- protein
- Length
- 527 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ap-2 complex subunit mu
- UniProt
- P84092
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 2% helix, 58% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ap-2 complex subunit mu | protein | 261 | 2% helix, 58% strand | P84092 |
| B | Ap-2 complex subunit mu | protein | 266 | 2% helix, 57% strand | P84092 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 739 | 0.74 | 0.79 | 67 | GOL |
| 2 | 564 | 0.63 | 0.75 | 57 | CIT |
| 3 | 104 | 0.41 | 0.77 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 675 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7OFP · Apo Structure of Mu2 Adaptin Subunit (Ap50) Of AP2 Clathrin Adaptor · the same entry in another collection · chain A against A, TM-score 1.00
- P84092 · AlphaFold monomer V2.0 prediction for ap-2 complex subunit mu (P84092) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P84092
- Elsewhere: RCSB PDB 7OFP · PDBe 7OFP · UniProt P84092
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