MolNFT v1 · #184067 · protein
Ntd of resting state GLUA1/A2 heterotertramer
7OCC · Glutamate receptor 1: “Ntd of resting state GLUA1/A2 heterotertramer”. Electron microscopy, 2 ligands (NAG, BMA), 13 pockets (best druggability 0.80). MolNFT v1 #184067 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OCC
- Type
- protein
- Length
- 1,480 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 1; Glutamate receptor 2
- UniProt
- P19490, P19491
- Ligands
- NAG, BMA
- Pockets
- 13 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor 1 | protein | 365 | 38% helix, 21% strand | P19490 |
| B, D | Glutamate receptor 2 | protein | 375 | 34% helix, 21% strand | P19491 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 18 copies · chains A, D, B, C
- BMA · beta-D-mannopyranose · sugar · 2 copies · chains D, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 898 | 0.80 | 0.83 | 103 | empty |
| 2 | 920 | 0.80 | 0.82 | 100 | empty |
| 3 | 382 | 0.70 | 0.82 | 62 | empty |
| 4 | 321 | 0.67 | 0.81 | 43 | empty |
| 5 | 306 | 0.64 | 0.80 | 37 | empty |
Interfaces
3 interfaces between chains.
- A–D · 1376 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 1372 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 380 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 glycan, 4 disulfide (N-glycosylation, disulfide).
Compared structures
- 7OCC · NTD of resting state GluA1/A2 heterotertramer · the same entry in another collection · chain D against D, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P19490 · AlphaFold monomer V2.0 prediction for glutamate receptor 1 (P19490) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19490
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 7OCC · PDBe 7OCC · UniProt P19490 · UniProt P19491
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