MolNFT v1 · #183095 · protein

Structure of tariquidar-bound ABCG2

7NEQ: “Structure of tariquidar-bound ABCG2”. Electron microscopy, 4 ligands (CLR, U9N, R1H). MolNFT v1 #183095 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7NEQ
Type: protein
Length: 1,582 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q9UNQ0
Ligands: CLR, U9N, R1H, NAG

Structure

electron microscopy · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	566	—	Q9UNQ0
C, E	—	protein	107	—	—
D, F	—	protein	118	—	—

Ligands and binding sites

CLR · Cholesterol · ligand · 3 copies · chains A, B
U9N · [(2~{S})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-decanoyloxy-propyl] octadecanoate · ligand · chains A, B
R1H · tariquidar · ligand · chains A, B
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, D, F, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7NEQ · Structure of tariquidar-bound ABCG2 · the same entry in another collection · chain B against B, TM-score 1.00
Q9UNQ0 · AlphaFold monomer V2.0 prediction for broad substrate specificity ATP-binding cassette… · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UNQ0
Elsewhere: RCSB PDB 7NEQ · PDBe 7NEQ · UniProt Q9UNQ0

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