UniProt Q9UNQ0
ATP-binding cassette sub-family G member 2 (Q9UNQ0)
ATP-binding cassette sub-family G member 2 (UniProt Q9UNQ0), EC 7.6.2.2: 25 experimental structures and 1 predicted model on GenesisL1, 15 ligands bound, 43 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UNQ0
- Protein
- ATP-binding cassette sub-family G member 2
- EC
- 7.6.2.2
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 15
- Pockets
- 43 · 3 records with a druggable one
Structures
26 records of Q9UNQ0 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5NJ3 | Structure of an ABC transporter: complete structure | electron microscopy | A, B | NAG | — |
| 5NJ3 | Structure of an ABC transporter: complete structure | electron microscopy | A, B | NAG | — |
| 5NJG | Structure of an ABC transporter: part of the structure that could be built de novo | electron microscopy | A, B | NAG | 7 (best 0.84) |
| 5NJG | Structure of an ABC transporter: part of the structure that could be built de novo | electron microscopy | A, B | NAG | — |
| 6ETI | Structure of inhibitor-bound ABCG2 | electron microscopy | A, B | NAG, BWQ | — |
| 6ETI | Structure of inhibitor-bound ABCG2 | electron microscopy | A, B | NAG, BWQ | — |
| 6FEQ | Structure of inhibitor-bound ABCG2 | electron microscopy | A, B | NAG, D6T | 19 (best 0.86) |
| 6FEQ | Structure of inhibitor-bound ABCG2 | electron microscopy | A, B | NAG, D6T | — |
| 6FFC | Structure of an inhibitor-bound ABC transporter | electron microscopy | A, B | BWQ | — |
| 6HBU | Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and magnesium | electron microscopy | A, B | ATP, MG | — |
| 6HCO | Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab | electron microscopy | A, B | NAG, FY5 | — |
| 6HCO | Cryo-EM structure of the ABCG2 E211Q mutant bound to estrone 3-sulfate and 5D3-Fab | electron microscopy | A, B | NAG, FY5 | — |
| 6HIJ | Cryo-EM structure of the human ABCG2-MZ29-Fab complex with cholesterol and pe lipids docked | electron microscopy | A, B | PEE, CLR, BWQ | — |
| 6HZM | Cryo-EM structure of the ABCG2 E211Q mutant bound to ATP and magnesium (alternative placement of… | electron microscopy | A, B | ATP, MG | — |
| 6VXF | Structure of apo-closed ABCG2 | electron microscopy | B, A | — | — |
| 6VXH | Structure of ABCG2 bound to imatinib | electron microscopy | A, B | CLR, STI | — |
| 6VXI | Structure of ABCG2 bound to mitoxantrone | electron microscopy | A, B | CLR, MIX | — |
| 6VXJ | Structure of ABCG2 bound to SN38 | electron microscopy | A, B | CLR, RS4 | — |
| 7NEQ | Structure of tariquidar-bound ABCG2 | electron microscopy | A, B | NAG, U9N, CLR, R1H | — |
| 7NEZ | Structure of topotecan-bound ABCG2 | electron microscopy | A, B | TTC, NAG | — |
| 7NFD | Structure of mitoxantrone-bound ABCG2 | electron microscopy | A, B | NAG, MIX | — |
| 7OJ8 | ABCG2 E1S turnover-2 state | electron microscopy | A, B | ATP, CLR, FY5 | — |
| 7OJH | ABCG2 topotecan turnover-1 state | electron microscopy | B, A | ATP, CLR, TTC | — |
| 7OJI | ABCG2 topotecan turnover-2 state | electron microscopy | A, B | TTC, CLR, PLC, ATP | — |
| 8BI0 | ABCG2 turnover-2 state with tariquidar bound | electron microscopy | A, B | ATP, CLR, PLC, MG, R1H | 17 (best 0.82) |
| Q9UNQ0 | AlphaFold monomer V2.0 prediction for broad substrate specificity ATP-binding cassette transporter… | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 13 records
- CLR · Cholesterol · in 9 records
- ATP · Adenosine-5'-triphosphate · in 6 records
- BWQ · ~{tert}-butyl 3-[(2~{S},5~{S},8~{S})-14-cyclopentyloxy-2-(2-methylpropyl)-4,7-bis(oxidanylidene)-3,6,17-triazatetracyclo[8.7.0.0^{3,8}.0^{11,16}]heptadeca-1(10),11,13,15-tetraen-5-yl]propanoate · in 4 records
- FY5 · estrone 3-sulfate · in 3 records
- MG · Magnesium ion · in 3 records
- TTC · (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]inolizino[1,2-B]-quinoline-3, 14(4H,12H)-dione · in 3 records
- D6T · ~{N}-[5-[1-[4-[2-[6-methoxy-7-[2-[2-(2-methoxyethoxy) ethoxy]ethoxy]-3,4-dihydro-1~{H}-isoquinolin-2-yl]ethyl]phenyl]-1,2,3-triazol-4-yl]-2-propanoyl-phenyl]quinoline-2-carboxamide · in 2 records
- MIX · 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl) amino]ethyl}amino)-9,10-anthracenedione · in 2 records
- PLC · Diundecyl phosphatidyl choline · in 2 records
- R1H · tariquidar · in 2 records
- PEE · 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine · in 1 record
- RS4 · 7-ethyl-10-hydroxycamptothecin · in 1 record
- STI · 4-(4-methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamide · in 1 record
- U9N · [(2~{S})-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-decanoyloxy-propyl] octadecanoate · in 1 record
Experiment against prediction
- 6HZM chain B against the predicted model Q9UNQ0: TM-score 0.98, RMSD 1.41 Å
- 6HZM chain A against the predicted model Q9UNQ0: TM-score 0.98, RMSD 1.42 Å
- 6HBU chain B against the predicted model Q9UNQ0: TM-score 0.97, RMSD 1.43 Å
- 6HBU chain A against the predicted model Q9UNQ0: TM-score 0.97, RMSD 1.43 Å
- 5NJG chain B against the predicted model Q9UNQ0: TM-score 0.95, RMSD 1.51 Å
- 5NJG chain B against the predicted model Q9UNQ0: TM-score 0.95, RMSD 1.51 Å
- 5NJG chain A against the predicted model Q9UNQ0: TM-score 0.95, RMSD 1.51 Å
- 5NJG chain A against the predicted model Q9UNQ0: TM-score 0.95, RMSD 1.51 Å
- 7OJI chain A against the predicted model Q9UNQ0: TM-score 0.95, RMSD 2.04 Å
- 7OJI chain B against the predicted model Q9UNQ0: TM-score 0.95, RMSD 2.04 Å
Elsewhere
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