MolNFT v1 · #182942 · protein
Structure of the mammalian importin A1 bound to the tdp-43 nls
7N9H · Importin subunit alpha-1: “Structure of the mammalian importin A1 bound to the tdp-43 nls”. X-ray diffraction, 2 pockets (best druggability 0.48). MolNFT v1 #182942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7N9H
- Type
- protein
- Length
- 445 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Tar DNA-binding protein 43
- UniProt
- P52292, Q13148
- Pockets
- 2 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Importin subunit alpha-1 | protein | 422 | 74% helix, 0% strand | P52292 |
| A | Tar DNA-binding protein 43 | protein | 23 | 0% helix, 0% strand | Q13148 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.48 | 0.85 | 14 | empty |
| 2 | 74 | 0.44 | 0.80 | 13 | empty |
Interfaces
1 interface between chains.
- C–A · 1434 Ų buried · 28 hydrogen bonds · protein-protein
Compared structures
- 7N9H · Structure of the mammalian importin a1 bound to the TDP-43 NLS · the same entry in another collection · chain C against C, TM-score 1.00
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain C against A, TM-score 0.99
- Q13148 · AlphaFold monomer V2.0 prediction for tar DNA-binding protein 43 (Q13148) · a predicted model of the same protein · chain A against A, TM-score 0.19
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52292
- Every structure of UniProt Q13148
- Elsewhere: RCSB PDB 7N9H · PDBe 7N9H · UniProt P52292 · UniProt Q13148
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