MolNFT v1 · #182933 · protein

State 1 of tcdb and FZD2 at PH5

7N95 · Frizzled-2: “State 1 of tcdb and FZD2 at PH5”. Electron microscopy, 15 pockets (best druggability 0.65). MolNFT v1 #182933 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7N95
Type: protein
Length: 2,433 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Frizzled-2; Toxin B
EC: 3.4.22.-
UniProt: Q14332, P18177
Pockets: 15 · best druggability 0.65

Structure

electron microscopy · 2 distinct chains · 0% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Frizzled-2	protein	121	0% helix, 0% strand	Q14332
A	Toxin B (EC 3.4.22.-)	protein	2312	0% helix, 0% strand	P18177

Pockets

15 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	875	0.65	0.73	108	empty
2	365	0.53	0.73	51	empty
3	181	0.41	0.73	43	empty
4	152	0.38	0.72	32	empty
5	122	0.35	0.73	36	empty

Compared structures

7N95 · state 1 of TcdB and FZD2 at pH5 · the same entry in another collection · chain A against A, TM-score 1.00
Q14332 · AlphaFold monomer V2.0 prediction for frizzled-2 (Q14332) · a predicted model of the same protein · chain B against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14332
Every structure of UniProt P18177
Elsewhere: RCSB PDB 7N95 · PDBe 7N95 · UniProt Q14332 · UniProt P18177

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.