UniProt Q14332
Frizzled-2 (Q14332)
Frizzled-2 (UniProt Q14332): 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q14332
- Protein
- Frizzled-2
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 8 · 2 records with a druggable one
Structures
10 records of Q14332 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6C0B | Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B | x-ray diffraction | B | NAG, PAM | 1 (best 0.72) |
| 6C0B | Structural basis for recognition of frizzled proteins by clostridium difficile toxin B | x-ray diffraction | B | NAG, PAM | — |
| 7N95 | state 1 of TcdB and FZD2 at pH5 | electron microscopy | B | — | 1 (best 0.35) |
| 7N95 | State 1 of tcdb and FZD2 at PH5 | electron microscopy | B | — | — |
| 7N97 | State 2 of TcdB and FZD2 at pH5 | electron microscopy | B | — | — |
| 7N97 | State 2 of tcdb and FZD2 at PH5 | electron microscopy | B | — | — |
| 7N9S | TcdB and frizzled-2 CRD complex | electron microscopy | B | — | 1 (best 0.35) |
| 7N9S | Tcdb and frizzled-2 crd complex | electron microscopy | B | — | — |
| 7X8P | Frizzled 2 CRD in complex with pF7_A5 Fab | x-ray diffraction | A, D | NAG, PAM | 5 (best 0.69) |
| Q14332 | AlphaFold monomer V2.0 prediction for frizzled-2 (Q14332) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7X8P chain A against the predicted model Q14332: TM-score 0.97, RMSD 0.84 Å
- 7X8P chain D against the predicted model Q14332: TM-score 0.97, RMSD 0.84 Å
- 6C0B chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.13 Å
- 6C0B chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.13 Å
- 7N9S chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.13 Å
- 7N9S chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.13 Å
- 7N95 chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.17 Å
- 7N95 chain B against the predicted model Q14332: TM-score 0.95, RMSD 1.17 Å
- 7N97 chain B against the predicted model Q14332: TM-score 0.91, RMSD 1.41 Å
- 7N97 chain B against the predicted model Q14332: TM-score 0.91, RMSD 1.41 Å
Elsewhere
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