MolNFT v1 · #182845 · protein
Structure of MMPL3 reconstituted into lipid nanodisc in the tmm bound state
7N6B · MMPL3 transporter: “Structure of MMPL3 reconstituted into lipid nanodisc in the tmm bound state”. Electron microscopy, 1 ligand (0HJ), 7 pockets (best druggability 0.79). MolNFT v1 #182845 on GenesisL1: 3D structure, binding sites…
- PDB
- 7N6B
- Type
- protein
- Length
- 757 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MMPL3 transporter
- UniProt
- I7G2R2
- Ligands
- 0HJ
- Pockets
- 7 · best druggability 0.79
Structure
electron microscopy · 1 distinct chain · 65% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | MMPL3 transporter | protein | 757 | 65% helix, 6% strand | I7G2R2 |
Ligands and binding sites
- 0HJ · 6-O-[(2S)-2-{(1S)-18-[(1R,2R)-2-hexylcyclopropyl]-1-hydroxyoctadecyl}tricosanoyl]-alpha-D-glucopyranosyl alpha-D-glucopyranoside · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 989 | 0.79 | 0.81 | 70 | 0HJ |
| 2 | 53 | 0.69 | 0.97 | 21 | empty |
| 3 | 198 | 0.69 | 0.87 | 25 | empty |
| 4 | 127 | 0.42 | 0.76 | 22 | empty |
| 5 | 57 | 0.38 | 0.81 | 12 | empty |
Compared structures
- 7N6B · Structure of MmpL3 reconstituted into lipid nanodisc in the TMM bound state · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7G2R2
- Elsewhere: RCSB PDB 7N6B · PDBe 7N6B · UniProt I7G2R2
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