Research workbench

Structure of MMPL3 reconstituted into lipid nanodisc in the tmm bound state

Analyse Structure of MMPL3 reconstituted into lipid nanodisc in the tmm bound state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7N6B
Type: protein
Length: 757 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: MMPL3 transporter
UniProt: I7G2R2
Ligands: 0HJ
Pockets: 7 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 65% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	MMPL3 transporter	protein	757	65% helix, 6% strand	I7G2R2

Ligands and binding sites

0HJ · 6-O-[(2S)-2-{(1S)-18-[(1R,2R)-2-hexylcyclopropyl]-1-hydroxyoctadecyl}tricosanoyl]-alpha-D-glucopyranosyl alpha-D-glucopyranoside · ligand · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	989	0.79	0.81	70	0HJ
2	53	0.69	0.97	21	empty
3	198	0.69	0.87	25	empty
4	127	0.42	0.76	22	empty
5	57	0.38	0.81	12	empty

Compared structures

7N6B · Structure of MmpL3 reconstituted into lipid nanodisc in the TMM bound state · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I7G2R2
Elsewhere: RCSB PDB 7N6B · PDBe 7N6B · UniProt I7G2R2

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.