MolNFT v1 · #182679 · protein
Cryo-EM structure of tacan in the H196A H197A mutant form (TMEM120A)
7N0L · Ion channel tacan: “Cryo-EM structure of tacan in the H196A H197A mutant form (TMEM120A)”. Electron microscopy, 1 ligand (COA), 5 pockets (best druggability 0.80). MolNFT v1 #182679 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7N0L
- Type
- protein
- Length
- 626 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ion channel tacan
- UniProt
- Q8C1E7
- Ligands
- COA
- Pockets
- 5 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ion channel tacan | protein | 313 | 78% helix, 0% strand | Q8C1E7 |
Ligands and binding sites
- COA · Coenzyme A · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 790 | 0.80 | 0.83 | 60 | COA |
| 2 | 780 | 0.80 | 0.83 | 59 | COA |
| 3 | 474 | 0.65 | 0.77 | 45 | empty |
| 4 | 464 | 0.65 | 0.77 | 45 | empty |
| 5 | 56 | 0.34 | 0.78 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 3255 Ų buried · 37 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8C1E7
- Elsewhere: RCSB PDB 7N0L · PDBe 7N0L · UniProt Q8C1E7
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