MolNFT v1 · #182660 · protein
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with aug-alpha
7N00 · ALK tyrosine kinase receptor: “Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with…”. Electron microscopy, 9 pockets (best druggability 0.73). MolNFT v1 #182660 on GenesisL1: 3D…
- PDB
- 7N00
- Type
- protein
- Length
- 806 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ALK tyrosine kinase receptor; ALK and ltk ligand 2
- EC
- 2.7.10.1
- UniProt
- Q9UM73, Q6UX46
- Pockets
- 9 · best druggability 0.73
Structure
electron microscopy · 2 distinct chains · 19% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | ALK tyrosine kinase receptor (EC 2.7.10.1) | protein | 346 | 9% helix, 23% strand | Q9UM73 |
| B, D | ALK and ltk ligand 2 | protein | 57 | 75% helix, 0% strand | Q6UX46 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 750 | 0.73 | 0.78 | 73 | empty |
| 2 | 681 | 0.71 | 0.78 | 70 | empty |
| 3 | 84 | 0.49 | 0.82 | 21 | empty |
| 4 | 56 | 0.44 | 0.83 | 13 | empty |
| 5 | 63 | 0.44 | 0.83 | 22 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1049 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 1046 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 604 Ų buried · 4 hydrogen bonds · protein-protein
- C–B · 137 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 136 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 7N00 · Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025… · the same entry in another collection · chain D against D, TM-score 1.00
- Q9UM73 · AlphaFold monomer V2.0 prediction for ALK tyrosine kinase receptor (Q9UM73) · a predicted model of the same protein · chain C against A, TM-score 0.92
- Q6UX46 · AlphaFold monomer V2.0 prediction for ALK and ltk ligand 2 (Q6UX46) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UM73
- Every structure of UniProt Q6UX46
- Elsewhere: RCSB PDB 7N00 · PDBe 7N00 · UniProt Q9UM73 · UniProt Q6UX46
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