MolNFT v1 · #182558 · protein
16-nm repeat microtubule doublet
7MWG · Tubulin alpha chain: “16-nm repeat microtubule doublet”. Electron microscopy, 3 ligands (GTP, GDP, MG), 9 pockets (best druggability 0.81). MolNFT v1 #182558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MWG
- Type
- protein
- Length
- 870 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tubulin alpha chain; Tubulin beta chain
- UniProt
- P41351, P41352
- Ligands
- GTP, GDP, MG
- Pockets
- 9 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 46% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tubulin alpha chain | protein | 440 | 45% helix, 17% strand | P41351 |
| B | Tubulin beta chain | protein | 430 | 47% helix, 17% strand | P41352 |
Ligands and binding sites
- GTP · Guanosine-5'-triphosphate · ligand · chains A, B
- GDP · Guanosine-5'-diphosphate · ligand · chains B
- MG · Magnesium ion · metal · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 208 | 0.81 | 0.95 | 43 | GTP, MG |
| 2 | 347 | 0.61 | 0.78 | 40 | empty |
| 3 | 235 | 0.61 | 0.80 | 38 | GDP |
| 4 | 298 | 0.59 | 0.78 | 30 | empty |
| 5 | 103 | 0.46 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1937 Ų buried · 27 hydrogen bonds · protein-protein
Compared structures
- 7MWG · 16-nm repeat microtubule doublet · the same entry in another collection · chain A against A, TM-score 1.00
- P41352 · AlphaFold monomer V2.0 prediction for tubulin beta chain (P41352) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P41351 · AlphaFold monomer V2.0 prediction for tubulin alpha chain (P41351) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P41351
- Every structure of UniProt P41352
- Elsewhere: RCSB PDB 7MWG · PDBe 7MWG · UniProt P41351 · UniProt P41352
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