MolNFT v1 · #182335 · protein

Crystal structure of the ZNF3 of nucleoporin NUP358/RANBP2 in complex with ran-GDP

7MNR · GTP-binding nuclear protein ran: “Crystal structure of the ZNF3 of nucleoporin NUP358/RANBP2 in complex with ran-GDP”. X-ray diffraction, 3 ligands (GDP, MG, ZN), 1 pocket (best druggability 0.39). MolNFT v1 #182335 on GenesisL1: 3D…

PDB: 7MNR
Type: protein
Length: 243 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: GTP-binding nuclear protein ran; E3 sumo-protein ligase RANBP2
EC: 2.3.2.-
UniProt: P62826, P49792
Ligands: GDP, MG, ZN
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	GTP-binding nuclear protein ran	protein	203	35% helix, 28% strand	P62826
B	E3 sumo-protein ligase RANBP2 (EC 2.3.2.-)	protein	40	10% helix, 15% strand	P49792

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
ZN · Zinc ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	87	0.39	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 844 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7MNR · Crystal Structure of the ZnF3 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P62826
Every structure of UniProt P49792
Elsewhere: RCSB PDB 7MNR · PDBe 7MNR · UniProt P62826 · UniProt P49792

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.