MolNFT v1 · #182334 · protein
Crystal structure of the ZNF2 of nucleoporin NUP358/RANBP2 in complex with ran-GDP
7MNQ · GTP-binding nuclear protein ran: “Crystal structure of the ZNF2 of nucleoporin NUP358/RANBP2 in complex with ran-GDP”. X-ray diffraction, 3 ligands (GDP, MG, ZN), 2 pockets (best druggability 0.50). MolNFT v1 #182334 on GenesisL1…
- PDB
- 7MNQ
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTP-binding nuclear protein ran; E3 sumo-protein ligase RANBP2
- UniProt
- P62826, P49792
- Ligands
- GDP, MG, ZN
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 2 distinct chains · 29% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTP-binding nuclear protein ran | protein | 202 | 34% helix, 27% strand | P62826 |
| B | E3 sumo-protein ligase RANBP2 | protein | 34 | 0% helix, 18% strand | P49792 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- ZN · Zinc ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 171 | 0.50 | 0.77 | 24 | empty |
| 2 | 53 | 0.33 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 785 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 7MNQ · Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62826
- Every structure of UniProt P49792
- Elsewhere: RCSB PDB 7MNQ · PDBe 7MNQ · UniProt P62826 · UniProt P49792
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