MolNFT v1 · #182102 · protein

Human CTPS1 bound to UTP, amppnp, and glutamine

7MGZ: “Human CTPS1 bound to UTP, amppnp, and glutamine”. Electron microscopy, 3 ligands (UTP, ANP, MG). MolNFT v1 #182102 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7MGZ
Type: protein
Length: 2,172 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P17812
Ligands: UTP, ANP, MG

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
F, O, P, Q	—	protein	543	—	P17812

Ligands and binding sites

UTP · Uridine 5'-triphosphate · ligand · 4 copies · chains F, P, Q, O
ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · 4 copies · chains F, P, O, Q
MG · Magnesium ion · metal · 8 copies · chains F, O, P, Q

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7MGZ · Human CTPS1 bound to UTP, AMPPNP, and glutamine · the same entry in another collection · chain P against P, TM-score 1.00
P17812 · AlphaFold monomer V2.0 prediction for CTP synthase 1 (P17812) · a predicted model of the same protein · chain F against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P17812
Elsewhere: RCSB PDB 7MGZ · PDBe 7MGZ · UniProt P17812

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