UniProt P17812
CTP synthase 1 (P17812)
CTP synthase 1 (UniProt P17812): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 5 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P17812
- Protein
- CTP synthase 1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 5 · 1 record with a druggable one
Structures
9 records of P17812 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2VO1 | Crystal structure of the synthetase domain of human CTP synthetase | x-ray diffraction | A, B | — | — |
| 2VO1 | Crystal structure of the synthetase domain of human CTP synthetase | x-ray diffraction | A, B | — | — |
| 5U03 | Cryo-EM structure of the human CTP synthase filament | electron microscopy | A, B, C, D | ATP, UTP | — |
| 7MGZ | Human CTPS1 bound to UTP, amppnp, and glutamine | electron microscopy | F, O, P, Q | UTP, MG, ANP | — |
| 7MH0 | Human CTPS1 bound to CTP | — | — | — | |
| 7MIF | Human CTPS1 bound to inhibitor R80 | electron microscopy | C, G, H, I | ZG4, MG, UTP | — |
| 7MIG | Human CTPS1 bound to inhibitor T35 | electron microscopy | C, A, B, E | ZFY, MG, UTP | — |
| 7MIG | Human CTPS1 bound to inhibitor T35 | electron microscopy | C, A, B, E | ZFY, MG, UTP | — |
| P17812 | AlphaFold monomer V2.0 prediction for CTP synthase 1 (P17812) | predicted | A | — | 5 (best 0.69) |
Ligands
- UTP · Uridine 5'-triphosphate · in 5 records
- MG · Magnesium ion · in 4 records
- ZFY · 2-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}-2-methyl-N-{5-[6-(trifluoromethyl)pyrazin-2-yl]pyridin-2-yl}propanamide · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- ATP · Adenosine-5'-triphosphate · in 1 record
- ZG4 · N-(1-{2-[(cyclopropanesulfonyl)amino]-1,3-thiazol-4-yl}cyclopropyl)-5-(6-ethoxypyrazin-2-yl)pyridine-2-carboxamide · in 1 record
Experiment against prediction
- 7MIG chain C against the predicted model P17812: TM-score 0.99, RMSD 0.78 Å
- 7MIG chain C against the predicted model P17812: TM-score 0.99, RMSD 0.78 Å
- 7MGZ chain F against the predicted model P17812: TM-score 0.99, RMSD 0.82 Å
- 7MIF chain C against the predicted model P17812: TM-score 0.99, RMSD 0.82 Å
- 2VO1 chain B against the predicted model P17812: TM-score 0.98, RMSD 0.65 Å
- 2VO1 chain B against the predicted model P17812: TM-score 0.98, RMSD 0.65 Å
- 2VO1 chain A against the predicted model P17812: TM-score 0.97, RMSD 0.82 Å
- 2VO1 chain A against the predicted model P17812: TM-score 0.97, RMSD 0.82 Å
- 5U03 chain A against the predicted model P17812: TM-score 0.97, RMSD 1.61 Å
Elsewhere
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