MolNFT v1 · #327456 · protein
AlphaFold monomer V2.0 prediction for CTP synthase 1 (P17812)
P17812: “AlphaFold monomer V2.0 prediction for CTP synthase 1 (P17812)”. 5 pockets (best druggability 0.69). MolNFT v1 #327456 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P17812
- Type
- protein
- Length
- 591 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x84C29Ef3da704f3F8077E18d9E11eBbbA2488271
- Molecule
- CTP synthase 1
- UniProt
- P17812
- Pockets
- 5 · best druggability 0.69
Structure
1 distinct chain · 39% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CTP synthase 1 | protein | 591 | 39% helix, 20% strand | P17812 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 105 | 0.69 | 0.92 | 19 | empty |
| 2 | 379 | 0.59 | 0.76 | 47 | empty |
| 3 | 278 | 0.53 | 0.75 | 37 | empty |
| 4 | 76 | 0.40 | 0.78 | 13 | empty |
| 5 | 67 | 0.35 | 0.77 | 18 | empty |
Compared structures
- 5U03 · Cryo-EM structure of the human CTP synthase filament · an experimental structure of the same protein · chain A against A, TM-score 0.92
- 7MGZ · Human CTPS1 bound to UTP, amppnp, and glutamine · an experimental structure of the same protein · chain A against F, TM-score 0.91
- 7MIG · Human CTPS1 bound to inhibitor T35 · an experimental structure of the same protein · chain A against C, TM-score 0.89
- 7MIG · Human CTPS1 bound to inhibitor T35 · an experimental structure of the same protein · chain A against C, TM-score 0.89
- 7MIF · Human CTPS1 bound to inhibitor R80 · an experimental structure of the same protein · chain A against C, TM-score 0.89
- 2VO1 · Crystal structure of the synthetase domain of human CTP synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.39
- 2VO1 · Crystal structure of the synthetase domain of human CTP synthetase · an experimental structure of the same protein · chain A against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17812
- Elsewhere: UniProt P17812 · AlphaFold DB P17812
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