MolNFT v1 · #182042 · protein
Structure of the phosphoinositide 3-kinase P110 gamma (PIK3CG) P101 (PIK3R5) complex
7MEZ · Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic…: “Structure of the phosphoinositide 3-kinase P110 gamma (PIK3CG) P101 (PIK3R5) complex”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #182042 on…
- PDB
- 7MEZ
- Type
- protein
- Length
- 1,536 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform…
- EC
- 2.7.1.137, 2.7.1.153, 2.7.1.154, 2.7.11.1
- UniProt
- P48736, O02696
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 2 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (EC 2.7.1.137, 2.7.1.153, 2.7.1.154, 2.7.11.1) | protein | 989 | 43% helix, 18% strand | P48736 |
| B | Phosphoinositide 3-kinase regulatory subunit 5 | protein | 547 | 45% helix, 18% strand | O02696 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1137 | 0.80 | 0.81 | 72 | empty |
| 2 | 345 | 0.69 | 0.82 | 52 | empty |
| 3 | 605 | 0.68 | 0.77 | 66 | empty |
| 4 | 301 | 0.67 | 0.82 | 26 | empty |
| 5 | 344 | 0.67 | 0.80 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 1393 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 7MEZ · Structure of the phosphoinositide 3-kinase p110 gamma (PIK3CG) p101 (PIK3R5) complex · the same entry in another collection · chain A against A, TM-score 1.00
- O02696 · AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 5… · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48736
- Every structure of UniProt O02696
- Elsewhere: RCSB PDB 7MEZ · PDBe 7MEZ · UniProt P48736 · UniProt O02696
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