MolNFT v1 · #299216 · protein
AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 5 (O02696)
O02696: “AlphaFold monomer V2.0 prediction for phosphoinositide 3-kinase regulatory subunit 5 (O02696)”. 15 pockets (best druggability 0.76). MolNFT v1 #299216 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O02696
- Type
- protein
- Length
- 877 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x882B14FbCEd9AA8538F421f0Fc2Be75789f3B8A0
- Molecule
- Phosphoinositide 3-kinase regulatory subunit 5
- UniProt
- O02696
- Pockets
- 15 · best druggability 0.76
Structure
1 distinct chain · 32% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoinositide 3-kinase regulatory subunit 5 | protein | 877 | 32% helix, 16% strand | O02696 |
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.76 | 0.80 | 56 | empty |
| 2 | 484 | 0.69 | 0.80 | 40 | empty |
| 3 | 406 | 0.58 | 0.75 | 41 | empty |
| 4 | 195 | 0.53 | 0.78 | 27 | empty |
| 5 | 212 | 0.51 | 0.76 | 25 | empty |
Compared structures
- 7MEZ · Structure of the phosphoinositide 3-kinase P110 gamma (PIK3CG) P101 (PIK3R5) complex · an experimental structure of the same protein · chain A against B, TM-score 0.57
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O02696
- Elsewhere: UniProt O02696 · AlphaFold DB O02696
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