MolNFT v1 · #181990 · protein
Insulin receptor ectodomain dimer complexed with two irpa-9 partial agonists
7MD5: “Insulin receptor ectodomain dimer complexed with two irpa-9 partial agonists”. Electron microscopy, 3 ligands (NAG, FUC, BMA). MolNFT v1 #181990 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7MD5
- Type
- protein
- Length
- 1,508 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P06213, P01308
- Ligands
- NAG, FUC, BMA
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 682 | — | P06213 |
| B | — | protein | 562 | — | P06213 |
| M, N | — | protein | 30 | — | P06213 |
| S, O, Q, U | — | protein | 21 | — | P01308 |
| T, P, R, V | — | protein | 30 | — | P01308 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 22 copies · chains A, B, R, P
- FUC · alpha-L-fucopyranose · sugar · 6 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 2 copies
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7MD5 · Insulin receptor ectodomain dimer complexed with two IRPA-9 partial agonists · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7MD5 · PDBe 7MD5 · UniProt P06213 · UniProt P01308
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