MolNFT v1 · #181810 · protein
Full length ALPHA1 glycine receptor in presence of 1MM glycine and 32UM tetrahydrocannabinol state 2
7M6R · Glycine receptor subunit ALPHAZ1: “Full length ALPHA1 glycine receptor in presence of 1MM glycine and 32UM tetrahydrocannabinol state 2”. Electron microscopy, 2 ligands (GLY, NAG), 20 pockets (best druggability 0.85). MolNFT v1…
- PDB
- 7M6R
- Type
- protein
- Length
- 1,750 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glycine receptor subunit ALPHAZ1
- UniProt
- O93430
- Ligands
- GLY, NAG
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 36% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Glycine receptor subunit ALPHAZ1 | protein | 350 | 36% helix, 27% strand | O93430 |
Ligands and binding sites
- GLY · Glycine · ligand · 5 copies · chains A, E, B, C, D
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A, B, C, D, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 959 | 0.85 | 0.86 | 128 | empty |
| 2 | 678 | 0.84 | 0.87 | 99 | empty |
| 3 | 571 | 0.80 | 0.85 | 74 | empty |
| 4 | 485 | 0.78 | 0.85 | 35 | empty |
| 5 | 618 | 0.73 | 0.80 | 69 | GLY |
Interfaces
5 interfaces between chains.
- C–D · 2157 Ų buried · 13 hydrogen bonds · protein-protein
- B–C · 2064 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 2062 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 2046 Ų buried · 12 hydrogen bonds · protein-protein
- A–E · 2027 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 7M6R · Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM… · the same entry in another collection · chain E against E, TM-score 1.00
- O93430 · AlphaFold monomer V2.0 prediction for glycine receptor subunit ALPHAZ1 (O93430) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O93430
- Elsewhere: RCSB PDB 7M6R · PDBe 7M6R · UniProt O93430
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