MolNFT v1 · #181780 · protein
Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246
7M5U · M-phase phosphoprotein 8: “Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246”. X-ray diffraction, 1 ligand (MN1). MolNFT v1 #181780 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7M5U
- Type
- protein
- Length
- 63 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- M-phase phosphoprotein 8; UNC5246
- UniProt
- Q99549
- Ligands
- MN1
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | M-phase phosphoprotein 8 | protein | 58 | 34% helix, 41% strand | Q99549 |
| B | UNC5246 | protein | 5 | 0% helix, 40% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 572 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 covalent, 1 modified (additive adduct, covalent ligand, nonstandard).
Compared structures
- 7M5U · Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246 · the same entry in another collection · chain A against A, TM-score 1.00
- Q99549 · AlphaFold monomer V2.0 prediction for M-phase phosphoprotein 8 (Q99549) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99549
- Elsewhere: RCSB PDB 7M5U · PDBe 7M5U · UniProt Q99549
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