Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 41% strand (DSSP).

Ligands and binding sites

• MN1 · 4-carboxypiperidine · ligand · chains A, B
• MOH · Methanol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 572 Ų buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 1 modified (additive adduct, covalent ligand, nonstandard).

Compared structures

• 7M5U · Crystal structure of human MPP8 chromodomain in complex with peptidomimetic ligand UNC5246 · the same entry in another collection · chain A against A, TM-score 1.00
• Q99549 · AlphaFold monomer V2.0 prediction for M-phase phosphoprotein 8 (Q99549) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q99549
• Elsewhere: RCSB PDB 7M5U · PDBe 7M5U · UniProt Q99549