MolNFT v1 · #181379 · protein
Structure of partial beta-hairpin lir from FNIP2 bound to gabarap
7LT6 · Folliculin-interacting protein 2,GAMMA-aminobutyric acid…: “Structure of partial beta-hairpin lir from FNIP2 bound to gabarap”. X-ray diffraction, 4 pockets (best druggability 0.85). MolNFT v1 #181379 on GenesisL1: 3D structure…
- PDB
- 7LT6
- Type
- protein
- Length
- 406 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein
- UniProt
- Q9P278, O95166
- Pockets
- 4 · best druggability 0.85
Structure
x-ray diffraction · 3 distinct chains · 28% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein | protein | 138 | 28% helix, 26% strand | Q9P278, O95166 |
| B | Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein | protein | 132 | 29% helix, 23% strand | Q9P278, O95166 |
| C | Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein | protein | 136 | 29% helix, 25% strand | Q9P278, O95166 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.85 | 0.86 | 68 | empty |
| 2 | 150 | 0.48 | 0.77 | 29 | empty |
| 3 | 68 | 0.38 | 0.78 | 17 | empty |
| 4 | 52 | 0.34 | 0.78 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1297 Ų buried · 23 hydrogen bonds · protein-protein
- B–C · 1205 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 1199 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 7LT6 · Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP · the same entry in another collection · chain A against A, TM-score 1.00
- O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain B against A, TM-score 0.83
- Q9P278 · AlphaFold monomer V2.0 prediction for folliculin-interacting protein 2 (Q9P278) · a predicted model of the same protein · chain A against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9P278
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 7LT6 · PDBe 7LT6 · UniProt Q9P278 · UniProt O95166
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