UniProt Q9P278
Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein (Q9P278)
Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated protein (UniProt Q9P278): 9 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 44 pockets. Binding sites, druggability and…
- UniProt
- Q9P278
- Protein
- Folliculin-interacting protein 2,Gamma-aminobutyric acid receptor-associated…
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 44 · 5 records with a druggable one
Structures
10 records of Q9P278 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6NZD | Cryo-EM Structure of the Lysosomal Folliculin Complex (FLCN-FNIP2-RagA-RagC-Ragulator) | electron microscopy | I | GDP | 9 (best 0.81) |
| 6NZD | Cryo-EM structure of the lysosomal folliculin complex (flcn-FNIP2- raga-ragc-ragulator) | electron microscopy | I | GDP | — |
| 6ULG | Cryo-EM structure of the FLCN-FNIP2-Rag-Ragulator complex | electron microscopy | N | GDP, GNP | 12 (best 0.80) |
| 6ULG | Cryo-EM structure of the flcn-FNIP2-rag-ragulator complex | electron microscopy | N | GDP | — |
| 7LSW | Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP | x-ray diffraction | A, B, C, D, E, F | SO4 | 16 (best 0.73) |
| 7LSW | Structure of full beta-hairpin lir from FNIP2 bound to gabarap | x-ray diffraction | A, B, C, D, E, F | SO4 | — |
| 7LT6 | Structure of Partial Beta-Hairpin LIR from FNIP2 Bound to GABARAP | x-ray diffraction | A, B, C | — | 4 (best 0.85) |
| 7LT6 | Structure of partial beta-hairpin lir from FNIP2 bound to gabarap | x-ray diffraction | A, B, C | — | — |
| 8DHB | Active FLCN GAP complex | electron microscopy | I | — | 3 (best 0.77) |
| Q9P278 | AlphaFold monomer V2.0 prediction for folliculin-interacting protein 2 (Q9P278) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7LSW chain C against the predicted model O95166: TM-score 0.80, RMSD 0.45 Å
- 7LSW chain C against the predicted model O95166: TM-score 0.80, RMSD 0.45 Å
- 7LSW chain D against the predicted model O95166: TM-score 0.80, RMSD 0.50 Å
- 7LSW chain D against the predicted model O95166: TM-score 0.80, RMSD 0.50 Å
- 7LSW chain A against the predicted model O95166: TM-score 0.79, RMSD 0.74 Å
- 7LSW chain A against the predicted model O95166: TM-score 0.79, RMSD 0.74 Å
- 7LSW chain B against the predicted model O95166: TM-score 0.79, RMSD 0.76 Å
- 7LSW chain B against the predicted model O95166: TM-score 0.79, RMSD 0.76 Å
- 6NZD chain I against the predicted model Q9P278: TM-score 0.96, RMSD 1.62 Å
- 6NZD chain I against the predicted model Q9P278: TM-score 0.96, RMSD 1.62 Å
Elsewhere
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